During construction (renovation or new construction), building air is full of dust and volatile organic compounds (VOCsVolatile organic compound. An organic compound that evaporates readily into the atmosphere; as defined by the U.S. Environmental Protection Agency, VOCs are organic compounds that volatize and then become involved in photochemical smog production.).
So, it’s best not to run the HVAC(Heating, ventilation, and air conditioning). Collectively, the mechanical systems that heat, ventilate, and cool a building. system at this time. Just, seal the openings and leave the system off until work is complete.